Table 4.
The Top 20 Genes Differentially Expressed Between Responders and Nonresponders to Ibrutinib plus Nivolumab Among All Patients with Non-Hodgkin's Lymphomaa.
| Gene | Description | Log FC | Adjusted p Value |
|---|---|---|---|
| Genes upregulated in the responder group | |||
| LEF1 | Lymphoid enhancer-binding factor 1 | 1.058 | 0.001 |
| BTLA | B and T lymphocyte associated | 1.095 | 0.001 |
| PATL2 | Protein associated with topoisomerase II homolog 2 (yeast) | 1.111 | 0.003 |
| SIDT1 | SID1 transmembrane family, member 1 | 0.872 | 0.015 |
| PYHIN1 | Pyrin and HIN domain family, member 1 | 1.261 | 0.016 |
| L3MBTL3 | l(3)mbt-like 3 (Drosophila) | 0.982 | 0.028 |
| FAM114A2 | Family with sequence similarity 114, member A2 | 0.545 | 0.028 |
| TBC1D15 | TBC1 domain family, member 15 | 0.400 | 0.028 |
| LEPROTL1 | Leptin receptor overlapping transcript-like 1 | 0.817 | 0.028 |
| SACS | Sacsin molecular chaperone | 0.905 | 0.028 |
| LMBRD1 | LMBR1 domain containing 1 | 0.808 | 0.028 |
| GCLC | Glutamate-cysteine ligase, catalytic subunit | 1.150 | 0.028 |
| APOL3 | Apolipoprotein L, 3 | 0.946 | 0.028 |
| SRBD1 | S1 RNA binding domain 1 | 0.658 | 0.028 |
| TIGIT | T cell immunoreceptor with Ig and ITIM domains | 0.562 | 0.032 |
| CCL4 | Chemokine (C—C motif) ligand 4 | 0.697 | 0.032 |
| MDM1 | Mdm1 nuclear protein | 0.725 | 0.032 |
| SUB1 | SUB1 homolog, transcriptional regulator | 0.850 | 0.032 |
| FCMR | Fc fragment of IgM receptor | 1.378 | 0.032 |
| GMFG | Glia maturation factor, gamma | 0.547 | 0.035 |
| Genes downregulated in the responder group | |||
| C5orf66 | Chromosome 5 open reading frame 66 | –0.503 | 0.053 |
| PAPPA | Pregnancy-associated plasma protein A, pappalysin 1 | –0.442 | 0.056 |
| CCDC120 | Coiled-coil domain containing 120 | –0.331 | 0.061 |
| SOX9 | SRY (sex determining region Y)-box 9 | –1.061 | 0.066 |
| STS | Steroid sulfatase (microsomal), isozyme S | –0.421 | 0.067 |
| LYPD6B | LY6/PLAUR domain containing 6B | –0.573 | 0.075 |
| ARR3 | Arrestin 3, retinal (X-arrestin) | –0.497 | 0.076 |
| LMOD1 | Leiomodin 1 (smooth muscle) | –0.328 | 0.081 |
| LOC102546294 | Uncharacterized LOC102546294 | –0.427 | 0.085 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | –0.472 | 0.085 |
| SPINK2 | Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | –0.545 | 0.090 |
| FGF14 | Fibroblast growth factor 14 | –0.509 | 0.092 |
| HMCN1 | Hemicentin 1 | –0.895 | 0.093 |
| ATG9B | Autophagy related 9B | –0.432 | 0.095 |
| ESRP2 | Epithelial splicing regulatory protein 2 | –0.554 | 0.099 |
| CASC15 | Cancer susceptibility candidate 15 (non-protein coding) | –0.472 | 0.103 |
| ZFHX3 | Zinc finger homeobox 3 | –0.340 | 0.103 |
| CLDN1 | Claudin 1 | –0.826 | 0.103 |
| SLC1A1 | Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | –0.430 | 0.103 |
| LARGE-AS1 | LARGE antisense RNA 1 | –0.494 | 0.103 |
a
Diffuse large B-cell lymphoma, follicular lymphoma, and Richter's transformation.