Table 5.
Most Enriched Pathways in Responders and Nonresponders to Ibrutinib plus Nivolumab among Patients with Non-Hodgkin's Lymphomaa.
| Pathway Name | NES | FDR pValue |
FWER pValue |
|---|---|---|---|
| Responders | |||
| Translationb | 2.98 | 0.000 | 0.000 |
| Metabolism of RNAb | 2.93 | 0.000 | 0.000 |
| SRP-dependent co-translational protein targeting to membraneb | 2.88 | 0.000 | 0.000 |
| IL12_2 pathwayc | 2.80 | 0.000 | 0.000 |
| HIV infectionb | 2.79 | 0.000 | 0.000 |
| Influenza life cycleb | 2.79 | 0.000 | 0.000 |
| Metabolism of mRNAb | 2.78 | 0.000 | 0.000 |
| Adaptive immune systemb | 2.73 | 0.000 | 0.000 |
| 3UTR-mediated translational regulationb | 2.71 | 0.000 | 0.000 |
| Host interactions of HIV factorsb | 2.71 | 0.000 | 0.000 |
| Processing of capped intron containing pre-mRNAb | 2.68 | 0.000 | 0.000 |
| CD8 TCR pathwayc | 2.68 | 0.000 | 0.000 |
| TCR signalingb | 2.67 | 0.000 | 0.000 |
| Interferon signalingb | 2.66 | 0.000 | 0.000 |
| Respiratory electron transport ATP synthesis by chemiosmotic coupling and heat production by uncoupling proteinsb | 2.66 | 0.000 | 0.000 |
| TCA cycle and respiratory electron transportb | 2.64 | 0.000 | 0.000 |
| Interferon gamma signalingb | 2.63 | 0.000 | 0.000 |
| TCR pathwayc | 2.60 | 0.000 | 0.000 |
| Signaling by the BCR | 2.59 | 0.000 | 0.000 |
| Antiviral mechanism by IFN-stimulated genesb | 2.59 | 0.000 | 0.000 |
| Nonresponders | |||
| Core matrisomed | –2.92 | 0.000 | 0.000 |
| Integrin 1 pathwayc | –2.77 | 0.000 | 0.000 |
| ECM glycoproteinsd | –2.74 | 0.000 | 0.000 |
| Cytochrome P450 arranged by substrate typeb | –2.58 | 0.000 | 0.000 |
| ECM receptor interactione | –2.56 | 0.000 | 0.000 |
| ECM organizationb | –2.48 | 0.000 | 0.000 |
| Phase 1 functionalization of compoundsb | –2.48 | 0.000 | 0.000 |
| Regulation of IGF activity by IGF-binding proteinsb | –2.48 | 0.000 | 0.000 |
| Cell-cell junction organizationb | –2.41 | 0.000 | 0.000 |
| Collagen formationb | –2.41 | 0.000 | 0.000 |
| A tetrasaccharide linker sequence is required for GAG synthesisb | –2.38 | 0.000 | 0.000 |
| ECM regulatorsd | –2.38 | 0.000 | 0.000 |
| Olfactory signaling pathwayb | –2.35 | 0.000 | 0.000 |
| Linoleic acid metabolisme | –2.32 | 0.000 | 0.002 |
| Avb3 integrin pathwayc | –2.30 | 0.000 | 0.003 |
| Collagensd | –2.29 | 0.000 | 0.003 |
| Tight junction interactionsb | –2.27 | 0.000 | 0.004 |
| Bile acid and bile salt metabolismb | –2.25 | 0.000 | 0.009 |
| Cell junction organizationb | –2.24 | 0.000 | 0.009 |
| Integrin 3 pathwayc | –2.23 | 0.000 | 0.009 |
a
Diffuse large B-cell lymphoma, follicular lymphoma, and Richter's transformation.
Databases:
b
REACTOME.
c
PID.
d
NABA.
e
KEGG
FDR, false discovery rate; FWER, family-wise error rate; NES, normalized enrichment score.