Figure 2.

Summary of differential gene expression identified from transcriptional profiling of whole blood from active cases, asymptomatic individuals, and cases treated with Amphotericin B. In (A) we show a heatmap based on expression levels of the 500 most variable probes seen in one experiment (Fakiola et al., 2019). Columns represent individual samples and rows individual probes. Dendrograms based on hierarchical clustering are shown on the top and left side of the heatmap. Experimental groups are color-coded across the top of the heatmap. Keys show color coding for active (=case) and treated (=treated) cases, asymptomatics (=Quantiferon or HighAb positive individuals), and endemic healthy controls (=EHC). In (B) we show a gene network produced using Ingenuity Pathway Analysis for 254 DEGs identified in a comparison of active cases with healthy controls. Genes are represented by nodes. Genes in red have increased expression and genes in green have decreased expression when comparing active cases with healthy controls. The more intense the color the larger the fold change values. (C) Key to functional class of molecules encoded by genes at the nodes in (B). Elements of this figure are redrawn with permission from the original publication (Fakiola et al., 2019).