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. 2020 Nov 25;11:586432. doi: 10.3389/fphys.2020.586432

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Copyright © 2020 Barriga and Theveneau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of neural crest migration. (A–C) Diagrams depicting the position of NC cells (shades of brown to magenta) with respect to the placodal region (light blue) at pre-migration (stage 18), early migration (stage 21), and late migration (stage 25). EMT is progressively implemented as NC migration proceeds. Brown NC cells are more epithelial while magenta star-shaped NC cells are more mesenchymal. Top and bottom rows shows lateral views and dorsal views, respectively. Orientations and structures are indicated on the figure. Ot. ves., otic vesicle.