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. 2020 Dec 9;16(12):126. doi: 10.1007/s11306-020-01750-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — SUMMER helps to reveal biological signals. a, b Receiver Operating Characteristic (ROC) curve of simulated data with log₂ fold-change (log2FC) = 0.1 (a) and 0.3 (b). FPR false positive rate, TPR true positive rate. c Venn diagram of overlapping Differentially Expressed (DE) metabolites between two tests: young vs old and old + 121 versus old. d Venn diagram of overlapping DE reactions between two tests: young vs old and old + 121 versus old. e Heatmap of significantly enriched KEGG pathways terms identified using DE metabolites/reactions of the two tests. FDR false discovery rate. f Network connected by the three common DE metabolites identified by two tests. Data presented using old + 121 versus old dataset. The interactive form of the whole network is included in Supplemental File 1. Color intensity indicates log2FC, red up-regulation, blue down-regulation, node size represents node connectivity, cpd compound (metabolite)