Fig. 2. Effects of kcnq1ot1 on plasma HDL-C levels and RCT in apoE^−/− mice.

A Plasma levels of TC, TG, HDL-C, and LDL-C were assessed by enzymatic methods (n = 10 per group). B–D J774 macrophages loaded with [³H]-cholesterol and ox-LDL were injected into the abdominal cavity of apoE^−/− mice (n = 5 per group). The radioactivity in the plasma, liver and feces were measured by a liquid scintillation counter. Data are represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001; ns not significant vs. control group.