Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 25;14:603647. doi: 10.3389/fnins.2020.603647

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Di Cintio, Dal Bo, Baboci, De Mattia, Polano and Toffoli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Immune checkpoint inhibitors (ICIs) targets in lymphnodes and in glioblastoma (GBM) tumor microenvironment (TME). Cytotoxic T lymphocyte protein 4 (CTLA-4) blockade mainly acts by targeting Tregs expressing CTLA-4 in lymphnodes. In the context of the GBM TME, programmed cell death protein receptor 1 (PD-1)/programmed death ligand (PD-L1) blockade can overcome the T cell exhaustion and reverse immunosuppression.