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. 2020 Nov 25;7:601206. doi: 10.3389/fmolb.2020.601206

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Copyright © 2020 Wu, Zhang, Chen, Tan, He and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alteration frequency of CXCRs and their correlation with overall survival (OS) and progression-free survival (PFS) of ccRCC patients. (A) The CXCRs mutation rate was 23.14% (118/510) in ccRCC patients. The top four highest mutation rates for CXCR family members were present in CXCR6 (10%), CXCR7 (CXCR7 is also called ACKR3, 7%), CXCR3 (6%), CXCR4 (6%), respectively. (B) Genetic alterations in CXCRs were significantly associated with OS of ccRCC patients (p < 0.05). (C) Genetic alterations in CXCRs were significantly related to PFS of ccRCC patients (P < 0.01).