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. 2020 Dec 2;40(49):9426–9439. doi: 10.1523/JNEUROSCI.2430-20.2020

Figure 7.

Figure 7.

Differential effects on stimulation of bulbar vagal integration nuclei mediated by the submedius thalamic nucleus. A, E, Schematic of experimental design showing bilateral microinjections of vehicle or 5-HT into the SubM, preceding microinjection of capsaicin into either the Pa5 (N = 8) or NTS (N = 8) to activate the central terminals of primary nociceptors. B–D, F–H, Representative chart traces show respiratory and blood pressure movements before and after bilateral microinjection of capsaicin (red line) into either the NTS (B) or Pa5 (F) following vehicle microinjection into the SubM. NTS capsaicin-evoked changes in respiratory frequency (C) and blood pressure (D) were unaffected, whereas Pa5 capsaicin-evoked changes in respiratory frequency (G), but not blood pressure (H), were significantly blunted by SubM 5-HT microinjection in anesthetized rats. Data are represented as the mean ± SD. ****p < 0.0001, SubM 5-HT versus SubM vehicle by Bonferroni's multiple-comparisons test (B).