Table 1.

Baseline respiratory measurements after CNO administration in naive (N = 6), naive + 3 mg/kg CNO (N = 6), control AAV + 3 mg/kg CNO (N = 9), and hM3D(Gq) + 3 mg/kg CNO rats (N = 10) rats

	Naive (N = 6)	Naive + 3 mg/kg CNO (N = 6)	Control AAV + 3 mg/kg CNO (N = 9)	hM3D(Gq) + 3 mg/kg CNO (N = 10)
Respiratory rate (breaths/min)	100.1 ± 6.89	93.23 ± 9.63	95.56 ± 7.18	99.92 ± 11.24
Inspiratory time (s)	0.24 ± 0.03	0.29 ± 0.03	0.26 ± 0.03	0.25 ± 0.05
Expiratory time (s)	0.35 ± 0.03	0.38 ± 0.05	0.39 ± 0.03	0.39 ± 0.05
Tidal volume (ml/breath)	1.81 ± 0.28	2.03 ± 0.43	1.97 ± 0.20	2.13 ± 0.37
Minute volume (ml/min)	178.3 ± 34.35	185.30 ± 30.57	184.60 ± 24.67	208.80 ± 51.34
Peak inspiratory flow rate (ml/min)	10.19 ± 3.80	11.77 ± 2.51	14.14 ± 2.69	14.96 ± 3.83
Peak expiratory flow rate (ml/min)	8.10 ± 1.84	9.59 ± 1.46	9.43 ± 0.98	10.35 ± 2.01
Penh	1.16 ± 0.34	1.00 ± 0.16	0.85 ± 0.17	1.00 ± 0.35

Measurements were taken 30 min after intraperitoneal CNO administration and represent the average 5 min of recording before the first nebulization (vehicle). Data are represented as the mean ± SD for each group, and no significant differences were found between groups as determined by one-way ANOVA.