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Signaling Cross Talk Between Aβ42-Expressing and WT Cells Results in Death of WT Cells
Activation of JNK in Aβ42-expressing clones triggers preferential cell death in WT clones, leading to a decrease in overall WT clone size over time. Although cell death occurs in Aβ42-expressing clones, WT clones are affected first. Aβ42-expressing clones with few or no remaining WT cells could also be observed.
