Figure 1.

Transcriptomic Profiling of Endocrine and Chronological Aging (Early and Late) Female Rat Hippocampus

Heatmap visualization of hippocampal differential gene expression analysis of Reg 9m, Irreg 9m, Acyc 9m, and Acyc 15m with respect to Reg 6m, pathway analysis focused on microglial reactivity, complement, lipid metabolism, transforming growth factor β (TGF-β) signaling, major histocompatibility complex (MHC) class I and class II, tumor necrosis factor (TNF) signaling, type I and type II interferon signaling, and T cell markers and signaling. ∗p < 0.05 for differential gene expression analysis of the biological groups with respect to Reg 6m; calculated using student t-test. Detailed p-values and adjusted p values<0.05 for the differential gene expression analysis with respect to Reg 6m are listed in Table S1).