Figure 6.

Translational Validation of Neuroinflammatory Gene Expression Profile

(A–D) Hippocampal gene expression analysis was conducted on Gene Expression Omnibus (GEO):GSE11882 on stratified age groups in females and males. Fold changes computed by GEO2R tool are plotted. MHC-II expression stratified by age in (A) females and (B) males. Markers for microglial and neuron communication stratified by age in (C) females and (D) males. Plotted as fold change with respect to 20–34 years as control. ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001 calculated by GEO2R tool.