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. 2021 Jan 5;6:15. doi: 10.21037/tgh.2020.02.02

Table 3. Structural neuronal receptors stimulated by luminal contents for sensory, motility & blood flow.

Epithelial receptors near mucous gel layer
   A. For nociception
    Acid-sensing ion channels (5 types)
    Orphan G-protein coupled receptor (50 types)
    Mechanosensitive K+, Ca2+ channels
    Transient receptor potential (2 types)
    Ionotropic P2X purinoceptors (4 types)
Epithelial & sub-epithelial receptors
   A. For digestive & peristaltic physiology
    5-HT receptors (7 types)
    Cholecystokinin CCK receptors
    Somatostatin SST receptors
    Mechanosensitive K+, Ca2+ channels
    Corticotropin-releasing factor receptor
    Adenosine receptors (2 types)
   B. For neurons
    Neurotrophic receptors
    Protease-activated receptors (2 types)
    Voltage-gated Ca2+ channels
    Voltage-gated K+ channels
    Tetrodotoxin-resistant Na+ channels
    Voltage-gated Ca2+ channels
    Voltage-gated K+ channels
Epithelial & subepithelial receptors
   C. For analgesia, motility, blood flow
    Bradykinin Receptors (2 types)
    Tachykinin receptors (3 types)
    Calcium-gene related peptide receptors
    Prostaglandin receptors (4 types)
    Cannabinoid CB1 receptors
    Opioid receptors-(3 types: m, k, d)
    Ionotropic & metabotropic glutamate receptors (IMGR)

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