Table 3. Structural neuronal receptors stimulated by luminal contents for sensory, motility & blood flow.
Epithelial receptors near mucous gel layer |
A. For nociception |
Acid-sensing ion channels (5 types) |
Orphan G-protein coupled receptor (50 types) |
Mechanosensitive K+, Ca2+ channels |
Transient receptor potential (2 types) |
Ionotropic P2X purinoceptors (4 types) |
Epithelial & sub-epithelial receptors |
A. For digestive & peristaltic physiology |
5-HT receptors (7 types) |
Cholecystokinin CCK receptors |
Somatostatin SST receptors |
Mechanosensitive K+, Ca2+ channels |
Corticotropin-releasing factor receptor |
Adenosine receptors (2 types) |
B. For neurons |
Neurotrophic receptors |
Protease-activated receptors (2 types) |
Voltage-gated Ca2+ channels |
Voltage-gated K+ channels |
Tetrodotoxin-resistant Na+ channels |
Voltage-gated Ca2+ channels |
Voltage-gated K+ channels |
Epithelial & subepithelial receptors |
C. For analgesia, motility, blood flow |
Bradykinin Receptors (2 types) |
Tachykinin receptors (3 types) |
Calcium-gene related peptide receptors |
Prostaglandin receptors (4 types) |
Cannabinoid CB1 receptors |
Opioid receptors-(3 types: m, k, d) |
Ionotropic & metabotropic glutamate receptors (IMGR) |
Arranged by Translational Medicine Clinic and Research Center Storrs © 2006.