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CAST overexpression prevents MV-induced activation of calpains. A) AAV9-CAST injections in diaphragm increase CAST expression in diaphragm fibers. B) Overexpression of CAST prevents MV-induced activation of calpains as determined by the calpain cleavage fragment of αII-spectrin. * = significantly different from CON, # = significantly different from MV, θ = significantly different from CON, CON-CAST, and MV-CAST.
