Fig. 5.

MV-induced calpain activation results in altered mitochondrial regulatory proteins. A) Calpain-cleaved PKC-δ cleavage fragment is increased with MV. B) Calpain-cleaved DRP1 cleavage fragment is increased with MV. C) MFN1 is decreased with MV. D) MFN2 is unchanged with prolonged MV. E) Phosphorylation of STAT3 is increased with MV and blunted with CAST overexpression. * = significantly different from CON, ^ = significantly different from CON-CAST, θ = significantly different from CON, CON-CAST, and MV-CAST.