TABLE 1.
High‐throughput sequencing group | qPCR validation group | ||||||||
---|---|---|---|---|---|---|---|---|---|
SR(n = 3) | PaAF(n = 3) | PeAF(n = 3) | F/X2 | P | SR(n = 20) | AF(n = 20) | F/X2 | P值 | |
Age(Y) | 65.33 ± 7.02 | 61.33 ± 7.77 | 59 ± 8.72 | 0.50 | .63 | 58.30 ± 10.36 | 55.25 ± 8.52 | 3 | .09 |
Male | 1 | 1 | 2 | 0.9 | .64 | 12 | 10 | 0.40 | .51 |
BMI(kg/m2) | 27.37 ± 2.22 | 29.20 ± 2.59 | 28.67 ± 2.74 | 0.42 | .68 | 26.91 ± 2.76 | 28.91 ± 2.65 | 0.61 | .44 |
Hypertension | 0 | 1 | 0 | 2.25 | .33 | 5 | 6 | 0.13 | .72 |
Stroke | 1 | 0 | 0 | 2.25 | .33 | 4 | 3 | 0.17 | .68 |
Blood biochemical parameters | |||||||||
WBC109/L | 5 ± 1.46 | 5.91 ± 0.84 | 6.87 ± 1.29 | 1.76 | .25 | 6.02 ± 2 | 6.85 ± 2.76 | 1.13 | .29 |
PLT 109/L | 186.67 ± 10.07 | 171.33 ± 16.80 | 185 ± 17.09 | 0.94 | .44 | 215.2 ± 46.30 | 220.30 ± 54.59 | 0.32 | .58 |
D‐di ug/ml | 0.25 ± 0.07 | 0.22 ± 0.46 | 0.14 ± 0.31 | 3.06 | .12 | 0.32 ± 0.26 | 0.24 ± 0.18 | 2.20 | .15 |
ALT U/L | 23 ± 6.56 | 13.67 ± 2.52 | 15 ± 5.57 | 2.86 | .13 | 27.35 ± 15.04 | 31.85 ± 23.30 | 2.40 | .13 |
Scr umol/L | 52 ± 13.75 | 63.67 ± 11.37 | 76 ± 5.29 | 3.74 | .08 | 63.90 ± 15.33 | 71.10 ± 19.78 | 0.90 | .35 |
UA umol/L | 397.76 ± 118.97 | 339 ± 123.60 | 407 ± 181.43 | 0.20 | .83 | 361.10 ± 81.14 | 350.95 ± 82.61 | 0.20 | .66 |
TG umol/L | 1.94 ± 0.71 | 2.34 ± 1.71 | 3.41 ± 1.32 | 1.01 | .42 | 1.62 ± 0.40 | 2.28 ± 0.79 | 9.72 | <.01 |
LDLmmol/L | 1.50 ± 0.66 | 2.51 ± 0.28 | 2.95 ± 0.58 | 5.89 | .04 | 2.02 ± 0.60 | 2.21 ± 0.79 | 1.61 | .21 |
CRPmmol/L | 1.47 ± 0.91 | 1.23 ± 0.64 | 1.07 ± 0.06 | 0.29 | .75 | 1.55 ± 2.81 | 2.06 ± 1.31 | 0.74 | .46 |
Cardiac ultrasound | |||||||||
LAAp mm | 34.67 ± 2.52 | 38.33 ± 4.16 | 45.33 ± 3.51 | 7.34 | .02 | 31.10 ± 2.85 | 36.40 ± 5.64 | 5.34 | .03 |
IVSd mm | 7.67 ± 0.58 | 8.67 ± 0.58 | 9.00 ± 1.00 | 2.60 | .15 | 8.2 ± 1.01 | 8.40 ± 0.88 | 0.58 | .45 |
LVEF% | 62.67 ± 4.04 | 53.00 ± 2.00 | 57.00 ± 8.38 | 1.12 | .39 | 60.20 ± 3.14 | 55.00 ± 6.37 | 6.15 | .02 |
Abbreviations: AF, atrial fibrillation; LAAp, anteroposterior diameter of left atrium; LDL, low‐density lipoprotein; LVEF, left ventricular ejection fraction; PaAF, paroxysmal AF group; PeAF, persistent AF group; SR, sinus rhythm; TG, triglyceride.