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Effects of SGLT2i on cardiovascular (a) and all cause death (b), by drug. Random effects model synthesizes the effect across all studies, and the prediction interval gives the 95% range for the result of a future SGLT2i trial. Event rates (per 1000 patient years) are shown for both the SGLT2i and the placebo arms. CKD, chronic kidney disease; CVOT, cardiovascular outcome trial; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio
