Figure 5.

miR-376c is transferred by EC-Evs into NCL-H1299 cells. (A) Transfection efficiency of miR-376c mimic in ECs detected by RT-qPCR, ^* p < 0.05 vs. ECs transfected with NC mimic; (B) miR-376c expression in NSCLC cells co-cultured with ECs transfected with NC mimic or miR-376c mimic measured by RT-qPCR, ^* p < 0.05 vs. NSCLC cells co-cultured with ECs transfected with NC mimic; (C) miR-376c expression in NSCLC cells co-cultured with ECs treated with miR-376c mimic plus GW4869 or DMSO measured by RT-qPCR, ^* p < 0.05 vs. NSCLC cells co-cultured with ECs treated with miR-376c mimic + DMSO. Statistical data were measurement data, and described as mean ± standard deviation. The one-way analysis of variance with Tukey’s post hoc test was used for comparison among multiple groups. The experiment was repeated 3 times independently.