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. 2020 Nov 18;12(570):eabd3876. doi: 10.1126/scitranslmed.abd3876

Fig. 1. aPL antibodies, NET release, and renal function.

Fig. 1

Serum samples were obtained from 172 patients hospitalized with COVID-19. (A and B) Patients were divided into two groups on the basis of whether their serum samples were positive (+) or negative (−) for the presence of aPL antibodies (positivity was based on the manufacturer’s threshold). Shown is the amount of calprotectin in serum, a measure of neutrophil activation (A), and the clinical estimated glomerular filtration rate (eGFR) (B) for the two groups. (C and D) Patients were divided into two groups on the basis of whether their serum samples were positive (+) or negative (−) for the presence of aPS/PT antibodies (IgG and IgM considered together); the manufacturer’s thresholds were used to determine positivity. Shown is the amount of calprotectin (C) and the eGFR (D) for the two groups. Groups were analyzed by an unpaired t test: *P < 0.05, **P < 0.01, and ***P < 0.001. Horizontal black bars represent the mean. For patients who had serum samples available at multiple time points, only the first available serum sample was used in this analysis.