Table 3.
Significantly top 30 enriched GO items of differentially expressed genes between two TIICS levels
| Ontology | Description | P value |
|---|---|---|
| GOTERM_BP_DIRECT | T cell activation | 6.57E-07 |
| extracellular structure organization | 8.60E-07 | |
| extracellular matrix organization | 9.25E-07 | |
| T cell differentiation | 1.59E-05 | |
| collagen fibril organization | 3.50E-05 | |
| cellular defense response | 0.000134 | |
| T cell receptor signaling pathway | 0.000231 | |
| positive T cell selection | 0.000252 | |
| extracellular matrix disassembly | 0.000575 | |
| lymphocyte differentiation | 0.000696 | |
| GOTERM_MF_DIRECT | extracellular matrix structural constituent | 4.46E-10 |
| MHC protein binding | 2.85E-07 | |
| extracellular matrix structural constituent conferring tensile strength | 2.85E-07 | |
| collagen binding | 4.11E-06 | |
| serine-type peptidase activity | 4.20E-05 | |
| serine hydrolase activity | 4.29E-05 | |
| serine-type endopeptidase activity | 4.54E-05 | |
| fibronectin binding | 0.001746 | |
| metalloendopeptidase activity | 0.001746 | |
| receptor ligand activity | 0.002964 | |
| GOTERM_CC_DIRECT | endoplasmic reticulum lumen | 0.026267 |
| lysosomal lumen | 0.018802 | |
| extracellular matrix component | 0.000321 | |
| T cell receptor complex | 0.000157 | |
| complex of collagen trimers | 1.20E-05 | |
| external side of plasma membrane | 7.43E-07 | |
| collagen trimer | 6.15E-07 | |
| fibrillar collagen trimer | 3.65E-07 | |
| banded collagen fibril | 3.65E-07 | |
| collagen-containing extracellular matrix | 7.80E-08 |