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. 2020 Nov 15;12(11):7002–7019.

Figure 3.

Figure 3

CTA in Cancer Immunotherapy. CTA vaccination (A) and strategy involving Adoptive transfer of CTA-specific T cells (B) induce immunity & cancer therapy. CTA vaccination (A), Step 1: Detection of CTAs in Tumors; Step 2: Treating patient with CTA-dependent protein/peptide/genetic variant along with pharmacological or immunological agents or Antigen Presenting Cells; Step 3: CD4, CD8 T cell and antibody response in vaccinated patient; Step 4: Spontaneous immunity in patient with advanced malignancy & metastasis. Adoptive transfer of CTA-specific T cells (B), Step 1: Detection of CTAs in Tumors and isolation of peripheral blood mononuclear cells (PBMCs); Step 2: Transfer Recombinant specific T cell receptors to PBMCs; Step 3: Expansion of T cells; Step 4: T cell treatment in patient; Step 5: Spontaneous immunity in patients with advanced malignancy & metastasis.