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Possible pathways of plasma phospholipid metabolism in acute rejection of renal transplantation. With the increase in FFA level produced by PCs, FFA can peroxide under oxidative stress, increase the rate of oxidative phosphorylation of mitochondria, and accelerate the process of β-oxidation through the TCA pathway to produce ATP to supply energy. Simultaneously, the increased FFA levels can also increase the rate of CDP-choline formation, leading to an increase in PC generation.
