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Effects of Dex, Vinp with Dex, and AT7867 with Dex on the Akt signaling pathway, apoptosis and ROS level. (A, B) Vinp significantly increased levels of p-Akt, an effect which could be partially reversed through the addition of Vinp or by treatment with AT7867. The effects of Vinp on apoptosis and ROS were abolished (C-F). The values are mean ± SD of five independent experiments. ##P < 0.01 compared with Dex group. **P < 0.01 compared with Dex+Vinp group.
