Figure 1.

Graphical display of combination index (CI) when pancreatic cancer cells (CFPAC) are treated with concentration of bromelain (Br), N-acetylcysteine (NAC) and in combination with various chemotherapeutic agents. Br and NAC at higher concentration shows synergy (A and B) whilst gemcitabine also synergises with Br, NAC and their combinations (C). 5FU at mid range concentrations also synergises with NAC or NAC + Br (D). Oxaliplatin only synergises with Br (E) whilst Doxorubicin synergises only with NAC (F). The dotted lines show a CI = 1.0 (additivity), CI<1.0 = synergy, CI>1.0 = sub-additivity.