Table 2.

Combination Index (CI) for ASPC-1 (Pancreatic cancer cells) treated with combination of different agents

Agent 1	Conc. mg/ml	Agent 2	Conc. µg/ml	CI		Agent 1	Conc. µg/ml	Agent 2	Conc. mg/ml	CI
NAC	0.082	BR	15	0.75		BR	7	NAC	0.163	0.65
			25	0.73					0.408	0.53
			50	0.54					0.816	0.26
			100	0.68					1.632	0.34
	0.409		5.0	0.81					2.447	0.45
			10	0.64			17		0.163	0.79
			15	0.37					0.408	0.33
			25	0.63					0.816	0.21
			50	0.55					1.632	0.15
			100	0.84					2.447	0.14
Agent 1	Conc. µg/ml	Agent 2	Conc. mg/ml	CI	Agent 3	Conc. µg/ml	CI	Combo (3 agents)		CI
GEM	0.026	NAC	0.407	0.84	BR	10	-	GEM + NAC + BR		-
	0.0132			0.51			-			-
	0.0263			0.43			-			0.75
	0.1315			-			0.23			0.71
	0.2632			0.65			0.25			0.60
5-FU	0.130	NAC	0.408	-	BR	10	0.56	5-FU + NAC + BR		-
	0.650			-			0.92			-
	1.30			-			0.77			-
	2.08			-			0.76			-
	3.25			-			-			-
	6.50			-			0.95			-
	13.0			-			0.72			-
CIS	0.15	NAC	0.407	-	BR	10	-
	0.3			-			-
	1.5			-			-
	3.0			-			0.37
	6.0			-			0.74
	12.0			-			-
OXA	0.397	NAC	0.407	-	BR	20	-	OXA + NAC + BR		-
	0.993			-			-			-
	1.986			-			-			-
	3.972			-			-			-
	5.959			-			-			-
	9.932			-			-			-
	19.86			-			0.93			-
Agent 1	Conc. ng/ml	Agent 2	Conc. mg/ml	CI	Agent 3	Conc. µg/ml	CI	Combo (3 agents)		CI
DOX	27.18	NAC	0.407	-	BR	10	-	DOX + BR + NAC		0.93
	54.35			-			-			0.59
	271			-			-			0.64
	543			-			-			0.51
	1359			0.42			0.02			0.46

CI values with 1.0 or >1 is not shown in the table. CI values <0.5 are highlighted to denote good synergy.