Table 5.
Shows the relative ratio of the two agents used to derive a low CI that is indicative of very good synergy (CI<0.5) in pancreatic cancer cells (CPFAC & ASPC1) and hepatic cancer cells (HEP3B & HEPG2)
| Cell line | NAC (µg/ml) | BR (µg/ml) | CI | Wt. ratio NAC:BR | Molecular ratio NAC:BR |
|---|---|---|---|---|---|
| CPFAC | 1632 | 20.0 | 0.43 | 82:1 | 0.5:3.5 × 10-5 |
| 8159 | 12.0 | 0.36 | 680:1 | 4.2:3.5 × 10-5 | |
| ASPC-1 | 2447 | 17.0 | 0.14 | 144:1 | 0.88:3.5 × 10-5 |
| 408 | 17.0 | 0.33 | 24:1 | 0.15:3.5 × 10-5 | |
| HEP3B | 2450 | 15.0 | 0.36 | 163:1 | 1.0:3.5 × 10-5 |
| 2450 | 25.0 | 0.39 | 98:1 | 0.6:3.5 × 10-5 | |
| HEPG2 | 815 | 10.0 | 0.34 | 81.5:1 | 0.5:3.5 × 10-5 |
| 8160 | 10.0 | 0.2 | 816:1 | 5.0:3.5 × 10-5 | |
| 1630 | 2.5 | 0.06 | 652:1 | 4.0:3.5 × 10-5 | |
| 1630 | 10.0 | 0.23 | 163:1 | 1.0:3.5 × 10-5 |
NAC = N-acetylcysteine; BR = bromelain; CI = Combination index. The highlighted figures indicate the best synergism of the combinations used.