Table 1.

Characteristics of studies included in the present meta-analysis

Study	Year	Country	Sample size (Patients/controls)	Mean age (Patients/controls)	Detected sample	miRNA	Detection method
Wu and Zhang (32)	2018	China	119/96	59±11/57±10	PBMCs	miRNA-126(down)	qPCR
Dong et al. (25)	2017	China	161/149	61.35±7.10/61.08±7.51	PBMCs	miRNA-24(up), miRNA-33a(up), miRNA-103a(up), miRNA-122(up)	qPCR
Quan et al. (29)	2018	China	73/59	65.67±11.59/59.67±9.86	Plasma	miRNA-146a	qRT-PCR
Amr et al. (24)	2018	Egypt	46/20	57.0±6.2/58.1±1.1	Blood	miRNA-126(down)	qRT-PCR
Faccini et al. (27)	2017	France	69/32	58.4±9.0/57.3±11.6	Plasma	let-7c(down), miRNA-145 (down), miRNA-155(down),	qRT-PCR
Guo et al. (28)	2018	China	300/100	56.2	Blood	miRNA-223	qRT-PCR
Sayed et al. (30)	2015	China	65/32	53	Plasma	miRNA-149(down), miRNA-424,(down), miRNA-765(up)	qRT-PCR
Wang et al. (31)	2014	China	92/34	65.2±10.5/59.4±13.1	Serum	miRNA-487a(up), miRNA-29b(up), miRNA-502(up),	qRT-PCR
					miRNA-208(up), miRNA-215(up)
Zhang et al. (35)	2017	China	290/110	59.2	Blood	miRNA-208a(up)	qRT-PCR
Zhang et al. (33)	2018	China	102/92	59.6±9.7/57.2±8.5	Plasma	miRNA-126(down), miRNA-210(down), miRNA-378(down),	qPCR
Zhou et al. (36)	2015	China	67/67	NA	Plasma	miRNA-260(up), miRNA-574-5p(up)	qRT-PCR
Zhang et al. (39)	2020	China	88/67	NA	Blood	miRNA-29a-3p(up), miRNA-574-3p(up), miRNA-574-5p (up)	qRT-PCR
Du et al. (26)	2016	China	40/40	34.20+5.93/36.58+3.96	Serum	miRNA-196b-5p (down), miRNA-3613-3p(down),	qRT-PCR
					miRNA-145-3p (down), miRNA-190a-5p(down)
Ali Sheikh et al. (23)	2015	China	69/20	72.53±4.31/71.7±5.2	Plasma	miRNA-765(up), miRNA-149	qRT-PCR

qPCR - quantitative real-time PCR; qRT-PCR - quantitative reverse transcription–PC; PBMCs - peripheral blood mononuclear cells; NA - data not available