Figure 1.

General Concept of Stem Cell Differentiation and Its Influences by Epigenetics

Pluripotent stem cells can differentiate into lineage-restricted progenies. Intrinsic properties of stem cells as well as extrinsic factors such as cell-cell signaling and metabolism influence stem cell self-renewal and differentiation. Progression from stem cell to differentiated progeny is accompanied by remarkable epigenetic changes from euchromatin to heterochromatin. Figure was created with BioRender.com.