Table 1.

Functions of Different HDAC Inhibitors in CSC Targeting

HDAC Inhibitor	Cancer Type	Effect on CSCs	Mechanism	Reference
SAHA	pancreatic	impairs self-renewal capacity	inhibition of miR-34a-Notch signaling and epithelial-mesenchymal transition	(Nalls et al., 2011)
	head and neck	reverses cisplatin resistance	downregulation of Nanog expression	(Kumar et al., 2015)
Mocetinostat	pancreatic	represses stemness/resensitization to chemotherapy	interference with ZEB1 and restoration of miR-203 expression	(Meidhof et al., 2015)
TSA and SAHA	endometrial adenocarcinoma	induction of differentiation	upregulation of glycodelin	(Uchida et al., 2005)
Abexinostat	breast	induction of differentiation	involvement of Xist and potentially BRCA1	(Salvador et al., 2013)
AR-42	leukemia	Apoptosis	inhibition of NF-κB and Hsp90 functions	(Guzman et al., 2014)
Romidepsin	leukemia	Apoptosis	upregulation of genes involved in the inflammatory response and apoptosis pathways	(Yan et al., 2019)