Figure 3.

Types of Genomic Contacts with the Nucleolus

Schema representing nucleolar-associated domains (NADs). Genomic contacts with the nucleolus have been identified by biochemical purification of the nucleoli and contacts with rRNA genes (HIC, 4C-seq) or rRNA transcripts (SPRITE). Some NADs were described to overlap with lamina-associated domains (LADs). The double arrow indicates the relocation of some NADs to the nuclear lamina after mitosis. Green lanes represent chromosomes bearing rRNA genes. Interchromosomal DNA contacts between chromosomes containing rRNA genes have been reported, mirroring the coalescence of rRNA genes from different chromosomes in the same nucleolus.