TABLE 2.
Infectious organisms cultured pre‐ and post‐immune checkpoint inhibitor.
| Infection type | Organism | Number of cases | |
|---|---|---|---|
| Pre‐Immunotherapy | Post‐immunotherapy | ||
| Cutaneous | 109 (32%) | 47 (24%) | |
| Bacterial | Staphylococcus aureus | 55 | 18 |
| Mixed anaerobic bacteria | 12 | 9 | |
| Enterobacter species | 6 | 3 | |
| Pseudomonas aeruginosa | 3 | 3 | |
| Streptococcus species | 3 | 1 | |
| Escherichia coli | 2 | 0 | |
| Fungal | Candida species | 7 | 5 |
| Viral | HSV/VZV | 6 | 4 |
| Genitourinary | 100 (30%) | 66 (33%) | |
| Bacterial | Escherichia coli | 56 | 31 |
| Klebsiella species | 12 | 8 | |
| Enterococcus faecalis/faecium | 6 | 4 | |
| Streptococcus species | 6 | 0 | |
| Citrobacter species | 3 | 2 | |
| Morganella morganii | 3 | 0 | |
| Pseudomonas aeruginosa | 2 | 3 | |
| Mixed anaerobic bacteria | 2 | 0 | |
| Proteus mirabilis | 1 | 3 | |
| Fungal | Candida species | 5 | 9 |
| Respiratory | 86 (26%) | 57 (29%) | |
| Bacterial | Staphylococcus aureus | 13 | 11 |
| Mixed anaerobic bacteria | 13 | 5 | |
| Haemophilus influenzae | 10 | 5 | |
| Enterobacter species | 7 | 1 | |
| Streptococcus pneumoniae | 4 | 2 | |
| Klebsiella pneumoniae/oxytoca | 4 | 0 | |
| Pseudomonas aeruginosa | 2 | 5 | |
| PJP | 2 | 3 | |
| Escherichia coli | 1 | 4 | |
| Moraxella catarrhalis | 1 | 1 | |
| Fungal | Candida albicans | 10 | 12 |
| Aspergillus species | 2 | 1 | |
| Viral | RSV, HMV, Rhinovirus, Adenovirus | 4 | 3 |
| HSV | 2 | 0 | |
| Bacteremia | 19 (6%) | 18 (9%) | |
| Escherichia coli | 6 | 5 | |
| Staphylococcus aureus | 2 | 3 | |
| Other staphylococcus species | 4 | 1 | |
| Klebsiella pneumoniae | 1 | 0 | |
| Streptococcus species | 1 | 3 | |
| Bacteroides fragilis | 1 | 0 | |
| Citrobacter freundii | 1 | 0 | |
| Proteus species | 0 | 2 | |
| Enterococcus faecalis | 0 | 1 | |
| Pseudomonas aeruginosa | 0 | 1 | |
| Gastrointestinal | 12 (4%) | 8 (4%) | |
| Bacterial | Campylobacter species | 2 | 1 |
| Escherichia coli | 1 | 1 | |
| Salmonella typhimurium | 1 | 0 | |
| Enterococcus faecium | 0 | 1 | |
| Pseudomonas aeruginosa | 0 | 1 | |
| Fungal | Candida species | 3 | 1 |
| Aspergillus fumigatus | 1 | 0 | |
| Viral | CMV | 0 | 0 |
| HSV1 | 0 | 1 | |
| Bone | 6 (2%) | 1 (1%) | |
| Bacterial | Escherichia coli | 2 | 0 |
| Staphylococcus aureus | 1 | 1 | |
| Staphylococcus epidermidis | 1 | 0 | |
| Viridans streptococcus | 1 | 0 | |
| Mixed anaerobic bacteria | 1 | 0 | |
| Ocular/CNS | 5 (1%) | 1 (1%) | |
| Bacterial | Staphylococcus aureus | 2 | 0 |
| Corynebacterium macginleyi | 1 | 0 | |
| Moraxella species | 1 | 0 | |
| Staphylococcus epidermidis | 1 | 0 | |
| Viral | HSV1 | 0 | 1 |
| Total | 337 (100%) | 198 (100%) | |
Representative examples within each organ‐site category are given, but the table does not display the complete list of microorganisms cultured.
Abbreviations: CNS, central nervous system; HMV, human metapneumovirus; HSV, herpes simplex virus; PJP, Pneumocystis jiroveci pneumonia; VZV, varicella zoster virus.