Table 2.

Tautomeric Equilibrium Reactions of Warfarin

Reaction	Equilibrium	Rule	pKT
A	T0 ↔ T1	prototropic (Rule 6)	1.04
B	T0 ↔ T2	prototropic (Rule 6)	9.78
C	T0 ↔ T3	prototropic (Rule 6)	12.62
D	T1 ↔ T4	prototropic (Rule 6)	−3.58
E	T1 ↔ T5	prototropic (Rule 6)	6.64
F	T1 ↔ T6	prototropic (Rule 6)	8.65
G	T4 ↔ T7	prototropic (Rule 6)	6.80
H	T4 ↔ T8	prototropic (Rule 6)	9.50
I	T5 ↔ T2	prototropic (Rule 6)	2.10
J	T5 ↔ T7	prototropic (Rule 6)	−3.42
K	T6 ↔ T3	prototropic (Rule 6)	2.93
L	T6 ↔ T8	prototropic (Rule 6)	−2.73
M	T0 ↔ T4	prototropic (Rule 7)	−2.54
N	T2 ↔ T7	prototropic (Rule 7)	−5.52
O	T3 ↔ T8	prototropic (Rule 7)	−5.67
P	T0 ↔ T9	ring chain	1.47
Q	T4 ↔ T10	ring chain	−1.91