Table 2.
Results of the evaluation of faecal microbiota transplantation (FMT) requests by multidisciplinary FMT expert panel.
| FMT decision | Number of requests |
|---|---|
| FMT request rejected by NDFB expert panel | 47/176 (27%) |
| Reasons of rejection of the 47 FMT requests: | |
| C. difficile carriership and diarrhoea due to other cause; | 30 (64%) |
| • Diarrhoea with unknown cause | –18 |
| • Diarrhoea due to IBD | –12 |
| Anti-CDI antibiotics advised instead of FMT; | 11 (23%) |
| • First, mild recurrence | –7 |
| • New CDI infection (too long interval between CDI episodes) | –4 |
| Long-term antibiotic use/elective operation | 3 (6%) |
| Withdrawal of FMT request after observed antibiotic treatment effect, by treating physician or patient | 3 (6%) |
| Request for FMT approved by NDFB expert panel | 129/176 (73%) |
| FMT indicationa | |
| • Multiple recurrent CDI | 125 (97%) |
| • Severe, therapy refractory CDI | 3 (2%) |
| • Refractory CDI | 1 (1%) |
CDI: Clostridioides difficile infection; IBD: inflammatory bowel disease.
aOne hundred and forty-three FMTs performed in 129 patients. Ten patients received multiple FMTs; nine patients for treatment of a post-FMT CDI relapse (seven patients cured with a single repeat FMT, one patient cured with two repeat FMTs, one patient cured with antibiotics after a repeat FMT) and one patient received sequential FMT treatment for severe, therapy refractory CDI (in total six FMTs; three FMTs for a first episode and three FMTs for the relapse).