Table 2.
Histologic parameters of the study population.
| Cohort 1 (n = 53) | Cohort 2 (n = 52) | Whole cohort (n = 105) | p Value | |
|---|---|---|---|---|
| AHHS | ||||
| Stage of fibrosis | ||||
| No fibrosis, portal fibrosis, extensive fibrosis (n, %) | 3 (6%) | 4 (8%) | 7 (7%) | 0.7 |
| Bridging fibrosis or cirrhosis (n, %) | 50 (94%) | 48 (92%) | 98 (93%) | |
| Bilirubinostasis | ||||
| No or hepatocellular only (n, %) | 26 (49%) | 31 (60%) | 57 (54%) | 0.5 |
| Canalicular or ductular (n, %) | 11 (21%) | 9 (17%) | 20 (19%) | |
| Canalicular or ductular plus hepatocellular (n, %) | 16 (30%) | 12 (23%) | 58 (27%) | |
| Polymorphonuclear infiltration | ||||
| No or mild (n, %) | 38 (72%) | 29 (56%) | 67 (64%) | 0.11 |
| Severe (n, %) | 15 (28%) | 23 (44%) | 38 (36%) | |
| Megamitochondria | ||||
| No megamitochondria (n, %) | 43 (81%) | 34 (65%) | 77 (73%) | 0.08 |
| Megamitochondria (n, %) | 10 (19%) | 18 (35%) | 28 (27%) | |
| AHHS categories | ||||
| Mild (0–3) (n, %) | 3 (6%) | 7 (13%) | 10 (9%) | 0.06 |
| Moderate (4–5) (n, %) | 11 (21%) | 18 (35%) | 29 (28%) | |
| Severe (6–9) (n, %) | 39 (74%) | 27 (52%) | 66 (63%) | |
| Laennec staging system | ||||
| 4A (n, %) | 7 (14%) | NA | NA | – |
| 4B (n, %) | 15 (31%) | NA | NA | |
| 4C (n, %) | 27 (55%) | NA | NA | |
AHHS: alcoholic hepatitis histologic score; NA: not available.