Table 3.

Risk factors for death at 6 months.

				All patients				Patients treated with corticosteroids
		Univariable		Multivariable model 1a		Multivariable model 2b		Multivariable model 1a		Multivariable model 2b
Baseline characteristics	Comparison group	Hazard ratio (95% CI)	p-Value	Hazard ratio (95% CI)	p-Value	Hazard ratio (95% CI)	p-Value	Hazard ratio (95% CI)	p-Value	Hazard ratio (95% CI)	p-Value
Age	1-Year increase	1.04 (1.01–1.07)	0.02	1.03 (0.99–1.06)	0.13	1.03 (0.98–1.09)	0.3	1.02 (0.98–1.05)	0.3	1.02 (0.96–1.09)	0.5
Gender	Male vs female	2.11 (0.92–4.83)	0.06
INR	1-Point increase	Not calculable
Bilirubin	1 µmol/l increase	1.00 (1.00–1.00)	0.001
Creatinine	1 mg/dl increase	1.00 (1.00–1.00)	<0.001
Albumin	1 g/dl increase	1.03 (0.95–1.12)	0.4
mDF	1-Point increase	1.12 (1.06–1.19)	<0.001
Child-Pugh score	1-Point increase	1.49 (1.22–1.83)	<0.001
MELD score	1-point increase	1.19 (1.13–1.26)	<0.001	1.12 (1.07–1.16)	<0.001	1.06 (0.98–1.14)	0.13	1.17 (1.10–1.23)	<0.001	1.07 (0.93–1.23)	0.4
ABIC score	1-Point increase	1.62 (1.02–2.58)	0.04
Lille score	1-Point increase	11.31 (4.29–29.82)	<0.001					5.16 (1.70–15.69)	0.004	17.30 (1.47–203.15)	0.02
Fibrosis	Yes vs no	1.01 (0.31–3.26)	1.0
Neutrophils	Yes vs no	0.48 (0.27–0.86)	0.01
Bilirubinostasis	1-Point increase	1.30 (0.93–1.80)	0.13
Megamitochondria	Yes vs no	0.98 (0.51–1.86)	0.9
AHHS	1-Point increase	0.97 (0.82–1.14)	0.7	0.94 (0.80–1.10)	0.4			1.00 (0.84–1.20)	1.0
Laennec 4B/4C	Yes vs no	1.69 (0.67–4.29)	0.3			4.31 (0.56–32.97)	0.16			7.47 (0.83–67.27)	0.07

ABIC: age, bilirubin, INR, creatinine; AHHS: alcoholic hepatitis histologic score; CI: confidence interval; INR: international normalised ratio; mDF: modified Maddrey discriminant function; MELD: model for end-stage liver disease.

^aAnalysis performed on the whole study population; ^banalysis performed on cohort 1.