Table 1. Effect of Vitamin D3 Supplementation During Pregnancy on PC Analyses of Motor Milestones.
| Outcomea | Vitamin D3 dose, mean (SD) | Unadjusted (n = 520) | Adjusted (N = 517)b | |||
|---|---|---|---|---|---|---|
| High (n = 261) | Standard (n = 259) | Effect, β (95% CI) | P value | Effect, β (95% CI) | P value | |
| PC1c | −0.04 (2.0) | −0.11 (2.0) | 0.07 (−0.27 to 0.42) | .67 | 0.08 (−0.26 to 0.43) | .64 |
| Girls | 0.19 (2.2) | −0.13 (1.9) | 0.32 (−0.18 to 0.82) | .21 | 0.30 (−0.20 to 0.81) | .24 |
| Boys | −0.24 (1.8) | −0.09 (2.1) | −0.15 (−0.62 to 0.32) | .53 | −0.13 (−0.61 to 0.34) | .58 |
| PC2d | −0.02 (1.4) | −0.13 (1.2) | 0.11 (−0.11 to 0.34) | .34 | 0.12 (−0.10 to 0.35) | .28 |
| Girls | −0.04 (1.4) | −0.14 (1.3) | 0.10 (−0.24 to 0.43) | .56 | 0.12 (−0.22 to 0.45) | .49 |
| Boys | −0.01 (1.3) | −0.12 (1.2) | 0.12 (−0.18 to 0.42) | .44 | 0.16 (−0.14 to 0.47) | .30 |
Abbreviation: PC, principal component.
a
Lower PC scores indicate younger age at milestone achievement.
b
Adjusted for maternal preintervention serum vitamin D3 levels, n-3 LCPUFA RCT allocation, season of birth, and for overall analyses additionally for sex. Three mothers were missing preintervention serum vitamin D3 levels.
c
Includes late gross motor milestones (ie, crawling, walking, and standing).
d
Includes early milestones (ie, smiling, head lifting, and sitting with support).