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. Author manuscript; available in PMC: 2020 Dec 9.
Published in final edited form as: Nat Rev Dis Primers. 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18

Figure 4. Cellular contributors to myofibroblast recruitment and subsequent tubulointerstitial fibrosis in DKD.

Figure 4.

The myofibroblasts responsible for the matrix deposition that leads to tubulointerstitial fibrosis in DKD are derived from a variety of sources, with transformation of local resident fibroblasts, mesenchymal stem cells and bone marrow derived fibrocytes and the induction of endothelial to mesenchymal and tubuloepithelial to mesenchymal transitions the main contributors.239