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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Semin Cancer Biol. 2020 Mar 10;67(Pt 2):117–130. doi: 10.1016/j.semcancer.2020.03.003

Fig. 3.

Fig. 3.

ITCH plays multifaceted roles in T cells.

The arrowhead from ITCH indicates positive regulation of the substrate protein, while the blunt head from ITCH indicates negative regulation of the substrate protein. Blue line indicates a K48-linked polyubiquitination of the substrate, while red line indicates a non-proteolytic linkage. The arrowhead towards ITCH indicates a positive regulation of ITCH E3 ligase activity, while the blunt head towards ITCH indicates negative regulation of ITCH E3 ligase activity.