Table 2.
Gene ontology enrichment analysis of human orthologs of the identified genes
| GO cellular component complete | Homo sapiens REFLIST (20,996) | Observed (19) | Expected | Fold enrichment | ± | Raw p-value | FDR |
|---|---|---|---|---|---|---|---|
| Azurophil granule lumen (GO:0035578) | 90 | 3 | 0.08 | 36.84 | + | 7.72E−05 | 1.94E−02 |
| → Azurophil granule (GO:0042582) | 154 | 3 | 0.14 | 21.53 | + | 3.63E−04 | 4.86E−02 |
| → Vesicle (GO:0031982) | 3868 | 11 | 3.5 | 3.14 | + | 1.45E−04 | 2.92E−02 |
| Primary lysosome (GO:0005766) | 154 | 3 | 0.14 | 21.53 | + | 3.63E−04 | 4.56E−02 |
| → Lysosome (GO:0005764) | 708 | 6 | 0.65 | 9.3 | + | 2.91E−05 | 9.73E−03 |
| → Lytic vacuole (GO:0000323) | 708 | 6 | 0.65 | 9.3 | + | 2.91E−05 | 1.17E−02 |
| → Vacuole (GO:0005773) | 809 | 6 | 0.74 | 8.14 | + | 6.10E−05 | 1.75E−02 |
| Secretory granule lumen (GO:0034774) | 320 | 4 | 0.29 | 13.81 | + | 1.79E−04 | 3.27E−02 |
| → Cytoplasmic vesicle lumen (GO:0060205) | 324 | 4 | 0.29 | 13.64 | + | 1.88E−04 | 3.14E−02 |
| → Vesicle lumen (GO:0031983) | 326 | 4 | 0.3 | 13.56 | + | 1.92E−04 | 2.97E−02 |
| Extracellular exosome (GO:0070062) | 2098 | 10 | 1.9 | 5.27 | + | 3.98E−06 | 7.99E−03 |
| → Extracellular vesicle (GO:1903561) | 2119 | 10 | 1.92 | 5.21 | + | 4.36E−06 | 4.37E−03 |
| → Extracellular organelle (GO:0043230) | 2124 | 10 | 1.92 | 5.2 | + | 4.45E−06 | 2.98E−03 |
| → Extracellular space (GO:0005615) | 3349 | 10 | 3.03 | 3.3 | + | 2.45E−04 | 3.51E−02 |
| Cytosol (GO:0005829) | 5229 | 14 | 4.76 | 2.94 | + | 1.21E−05 | 6.08E−03 |
| Protein-containing complex (GO:0032991) | 5520 | 13 | 5.03 | 2.58 | + | 1.59E−04 | 3.55E−02 |
Presented hierarchically with the most specific subclass first, with its parent terms directly below it. Related classes in an ontology are grouped. Results shown for false discovery rate (FDR) < 0.05. (geneontology.org, 22.5.20)