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. 2020 Dec 8;52:72. doi: 10.1186/s12711-020-00592-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Co-association network based on the AWM and transcriptomics data. a Full network with 1313 genes and 94 miRNAs; b Subset of the network showing the transcription factor CARF and all its predicted interactions; c Subset of the network with the TRAPPC2L interactions, which included several miRNAs; d Subset of the network with the CHD2 gene interactions. The node color corresponds to the phenotype group with the highest correlation value, as follows: concentration (red), abnormal acrosomes (green), abnormalities and droplets (pink), osmotic resistance test (orange), motility (light blue) and viability (dark blue). miRNAs are depicted in yellow. Node and text sizes correspond to the number of significant phenotypes correlated with that gene or miRNA. Nodes with a black line border correspond to genes identified in the shared network. Node shape indicates classification as: triangle (TF), V (TF co-factor) and ellipse (other genes and miRNAs)