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. 2020 Dec 1;3(6):1371–1380. doi: 10.1021/acsptsci.0c00179

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© 2020 American Chemical Society

This article is made available via the ACS COVID-19 subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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(A) Schematic representation of mNeonGreen pseudovirus reporter protein accumulation in HEK293T cells and the efficacy of T-Fc-IVM-NP showing inhibition of both ACE2 and pseudovirus uptake under (B) therapeutic and (C) preventative treatment methods as measured by the microplate reader. Confocal microscopy images revealing the changes in the expression of red-tagged ACE2 receptor on the cell membrane and mNeonGreen pseudovirus accumulation in the nucleus following the treatment of articles under (D) therapeutic and (E) preventative treatment methods. The article concentration was kept at 10 μM with respect to IVM for 4 h followed by an additional 20 h of incubation.