Table 5.
Key pathways regulated by CD82 in prostate cancer cells from top 100 significant genes from all three data array sets
| Gene Name | Gene ID | Gene Description | PC3–57 Array (logFC) |
PC3–29 Array (logFC) |
PrEC-31 Array (logFC) |
|---|---|---|---|---|---|
| Cell proliferation and angiogenesis | |||||
| ANXA3 | NM_002754.3 | Homo sapiens annexin A3 | + 0.504 | + 1.302 | + 1.218 |
| MAPK3 | NM_002754 | Homo sapiens mitogen-activated protein kinase 13 | + 0.715 | + 0.874 | + 0.816 |
| LXN | NM_020169 | Homo sapiens latexin | + 2.255 | + 1.220 | + 1.323 |
| RUNX3 | NM_001031680 | Homo sapiens runt-related transcription factor 3, transcript variant 1 | + 2.539 | + 1.446 | −1.140 |
| PIK3CA | NM_006218.2 | Homo sapiens phosphoinositide-3-kinase, catalytic, alpha polypeptide | −0.648 | − 0.903 | + 0.523 |
| CDKN1C | NM_000076 | Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) | −1.105 | − 1.319 | − 3.227 |
| BST2 | NM_004335 | Homo sapiens bone marrow stromal cell antigen 2 | −4.338 | −1.592 | + 0.926 |
| Migration & Invasion | |||||
| TFF3 | NM_003226 | Homo sapiens trefoil factor 3 (intestinal) | + 3.835 | + 2.071 | + 0.926 |
| CXCL2 | NM_002089 | Homo sapiens chemokine (C-X-C motif) ligand 2 | −1.521 | −1.422 | + 1.699 |
| Cell Apoptosis | |||||
| LCK | NM_005356 | Homo sapiens lymphocyte-specific protein tyrosine kinase, transcript variant 2 | + 1.377 | + 0.930 | −0.777 |
| STEAP1 | NM_012449 | Homo sapiens six transmembrane epithelial antigen of the prostate 1 | −1.498 | −1.912 | – |
| Cell cycle | |||||
| RUNX3 | NM_001031680 | Homo sapiens runt-related transcription factor 3, transcript variant 1 | + 2.539 | + 1.446 | −1.140 |
| CDKN1C | NM_000076 | Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) | −1.105 | −1.319 | −3.227 |
| LCK | NM_005356 | Homo sapiens lymphocyte-specific protein tyrosine kinase, transcript variant 2 | + 1.377 | + 0.930 | −0.776 |
| FGF13 | NM_004114.3 | Homo sapiens fibroblast growth factor 13 | − 0.765 | − 3.955 | – |
| Signal transduction pathways | |||||
| MAPK13 | NM_002754 | Homo sapiens mitogen-activated protein kinase 13 | + 0.715 | + 0.874 | + 0.816 |
| LCK | NM_005356 | Homo sapiens lymphocyte-specific protein tyrosine kinase, transcript variant 2 | + 1.377 | + 0.930 | −0.777 |
| PIK3CA | NM_006218.2 | Homo sapiens phosphoinositide-3-kinase, catalytic, alpha polypeptide | −0.648 | − 0.903 | + 0.523 |
| CXCL2 | NM_002089 | Homo sapiens chemokine (C-X-C motif) ligand 2 | −1.521 | −1.422 | + 1.699 |
| FGF13 | NM_004114.3 | Homo sapiens fibroblast growth factor 13 | − 0.765 | − 3.955 | – |
| WNT5A | NM_003392.3 | Homo sapiens wingless-type MMTV integration site family, member 5A | − 0.577 | − 1.094 | + 1.634 |
| PPFIA4 | NM_015053 | Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | −1.192 | − 1.649 | + 2.211 |
| Metabolic pathways | |||||
| TFF3 | NM_003226 | Homo sapiens trefoil factor 3 (intestinal) | + 3.835 | + 2.071 | + 0.926 |
| MMP23B | NM_006983 | Homo sapiens matrix metallopeptidase 23B | + 0.987 | + 0.889 | – |