Table 4.

Odds ratios for specific clinically and laboratory-based syndromes

Diagnosis	G6PD c.202T heterozygous girls		G6PD c.202T homozygous girls and hemizygous boys
	OR (95% CI)*	P	OR (95% CI)*	P
Clinical syndromes*
All-cause hospital admissions	0.81 (0.73-0.90)	<.0001	1.10 (0.98-1.19)	.13
Neonatal
All-cause neonatal admissions	0.65 (0.47-0.90)	.009	1.03 (0.77-1.38)	.84
Neonatal bacteremia	1.64 (0.70-3.86)	.25	1.26 (0.59-2.89)	.59
Neonatal jaundice	1.70 (1.12-2.58)	.013	3.06 (2.30-4.08)	<.0001
Postneonatal
All-cause postneonatal admissions	0.81 (0.73-0.90)	<.0001	1.02 (0.92-1.14)	.65
Bacteremia	1.45 (1.03-2.03)	.033	1.12 (0.81-1.56)	.49
Severe malaria	0.88 (0.64-1.21)	.43	0.86 (0.60-1.24)	.42
Malaria	0.88 (0.74-1.03)	.12	0.97 (0.83-1.14)	.75
Severe anemia	1.06 (0.79-1.43)	.72	1.13 (0.85-1.51)	.40
Meningitis/encephalitis	0.88 (0.74-1.05)	.15	1.22 (1.05-1.44)	.012
Severe malnutrition	1.17 (0.94-1.47)	.17	1.01 (0.78-1.30)	.94
Very severe pneumonia	0.83 (0.74-0.94)	.004	1.00 (0.89-1.12)	.96
Severe pneumonia	0.70 (0.40-1.22)	.21	1.77 (1.15-2.70)	.009
Gastroenteritis	0.91 (0.76-1.10)	.33	0.98 (0.83-1.16)	.83
Jaundice	0.87 (0.39-1.97)	.75	2.47 (1.41-4.33)	.002
Other	0.81 (0.61-1.07)	.13	0.81 (0.63-1.04)	.093
Nonmutually exclusive syndromes
Severe anemia	1.03 (0.75-1.40)	.87	1.09 (0.80-1.48)	.59
Malaria blood film positive	0.79 (0.68-0.93)	.004	0.99 (0.85-1.15)	.87
Transfused	0.91 (0.68-1.23)	.55	1.66 (1.29-2.15)	<.0001
Died	0.74 (0.53-1.05)	.93	1.37 (1.03-1.82)	.03

OR, odds ratio.

^*Some children displayed >1 clinical feature and therefore appear more than once. ORs derived through comparison of allele frequencies in cases vs community controls by logistic regression with adjustment for division of residence, sex, and HbS genotype. We found no evidence for an interaction between HbS and G6PD c202 genotype with regard to malaria risk.