Table I.
Relative expression of DNMT1, DNMT3A and DNMT3B in human colorectal carcinoma cells (HT-29) exposed to CdCl2 and CuSO4 normalized to control (unstimulated cells).
| CdCl2 (µg/ml) | CuSO4 (µg/ml) | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | 0.05 | 1 | 10 | 100 | 0.05 | 1 | 10 | 100 |
| DNMT1 | -3.72 | -5.67 | -8.69 | -1.03 | 18.58 | 16.81 | 17.3 | 11.69 |
| (-0.24) | (-0.64) | (-0.54) | (-0.23) | (3.83) | (3.20) | (2.93) | (1.25) | |
| DNMT3A | 5.72 | 1.03 | -17.12 | -7.19 | 0 | 0 | 0 | 0 |
| (0.45) | (0.13) | (-1.98) | (-0.87) | - | - | - | - | |
| DNMT3B | -2.85 | -5.82 | -13.7 | -8.7 | 22.19 | 12.64 | 25.53 | 21.02 |
| (-0.45) | (-0.38) | (-1.67) | (-0.63) | (2.54) | (1.45) | (2.86) | (3.45) | |