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. 2020 Dec 9;11:528. doi: 10.1186/s13287-020-02047-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Exploratory data analysis and summarization of differential gene expression for targeted expression profiles of canine reprogramming intermediates. a Schematic of canine fetal fibroblast (cFF) reprogramming and timepoints of RNA sample collection. b Hierarchical clustering analysis of all samples based on gene expression. c Principal component analysis of all samples based on gene expression. d Correlation heatmap of all samples based on gene expression. Sequential color scale represents Kendall’s rank correlation coefficient. e Venn diagram showing the number of differentially expressed genes versus the 6 DPI vehicle (VEH) group for 6 DPI AA/RA (red) and 6 DPI DMOG/AA/RA (blue). f Venn diagram showing the number of differentially expressed genes for AA/RA versus the corresponding DMOG/AA/RA group at 6 DPI (red) and 10 DPI (blue)