TABLE 3.

Practical aspects of treatment with antipsychotic combinations

Evidence on antipsychotic combinations’ effectiveness is limited	Managing antipsychotic combinations	Switching back to monotherapy
Patients maintained on a combination antipsychotics longer than 10 weeks (18–20)	Watch for drug interactions, metabolic syndrome, motor side effects, hyperprolactinemia	(Re)consider clozapine; resolve barriers preventing access
Antipsychotic combinations including clozapine (18)	Work closely with primary care to monitor patient	Consider the risk of symptom relapse (19, 20)
Treatment simultaneously initiated with 2 antipsychotics (13, 18)		Monitor all domains of illness
Patients with refractory schizophrenia and no practical access to clozapine		Anticipate medication discontinuation (19)