Table 1.
Clinical parameters of the animals
| CON (n = 9) | D-CON (n = 7–8) | BB (n = 8) | ACEI (n = 9) | AA (n = 11) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Days | 0 | 49 | 74 | 0 | 49 | 74 | 0 | 49 | 74 | 0 | 49 | 74 | 0 | 49 | 74 |
| BW (g) | 336.11 ± 12.29§^ˇ | 472.89 ± 9.05#+§^ˇ | 515.44 ± 11.91#†+§^ˇ | 324.25 ± 8.48^ˇ | 350.25 ± 7.38#*§^ | 320.5 ± 17.87* | 306.13 ± 4.19* | 323.13 ± 10.21* + | 302.75 ± 8.25†* | 297.67 ± 4.16* + | 313 ± 6.76#*+ | 306.89 ± 9.98* | 304.55 ± 4.56*+ | 327.36 ± 7.68#* | 300.36 ± 10.43†* |
| tBMI | 154.85 ± 4.42+§^ | 220.85 ± 8.97#+^ ˇ | 244.1 ± 9.63#†+§^ˇ | 176.28 ± 6.23* | 192.15 ± 6.97#* | 179.08 ± 11.6* | 194.18 ± 12.15*ˇ | 204.67 ± 13.8 | 192.05 ± 12.82†*ˇ | 173.94 ± 7.2* | 182.64 ± 7.24#* | 179.07 ± 8.43* | 164.85 ± 4.91§ | 177.18 ± 6.26#* | 159.67 ± 6.21†*§ |
| CON (n = 9) | D-CON (n = 7) | BB (n = 8) | ACEI (n = 9) | AA (n = 11) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Days | 0 | 7 | 39 | 0 | 7 | 39 | 0 | 7 | 39 | 0 | 7 | 39 | 0 | 7 | 39 |
| SBP | 124.22 ± 2.44§ | 135.64 ± 6.92^ | 131.16 ± 6.39+^ | 132.74 ± 6.63 | 137.34 ± 4.67^ | 157.69 ± 6.07#†*^ˇ | 135.88 ± 3.69* | 124.95 ± 5.55#^ | 136 ± 9.65^ | 142.8 ± 9.7 | 96.2 ± 5.86#+*§ˇ | 101.9 ± 5.49#*+§ˇ | 134.07 ± 4.11 | 129.67 ± 5.24^ | 135.38 ± 6.39+^ |
| DBP | 93.33 ± 2.05§ | 107.31 ± 7.12§^ | 100.53 ± 5.45^ | 104.31 ± 5.44 | 104.34 ± 5.54^ | 117.94 ± 4.08#†^ˇ | 103.68 ± 3.97* | 91.23 ± 5.34#*^ | 108.85 ± 7.32^ | 112.7 ± 8.26 | 68.73 ± 3.67#*+§ˇ | 74.65 ± 4.58#*+§ˇ | 98.58 ± 4.79 | 94.05 ± 4.08^ | 93.62 ± 6.53+^ |
| HR | 427.62 ± 9.23ˇ | 424.13 ± 10.52§ | 405.09 ± 8.87†§ | 406.31 ± 17.7 | 409.91 ± 9.9§ | 446.86 ± 23.42§^ | 403.7 ± 10.82 | 331.4 ± 5.97#*+^ˇ | 339.85 ± 8.83#*+^ˇ | 410.78 ± 8.88 | 408.85 ± 6.97§ | 384.3 ± 12.36+§ | 404.45 ± 5.19* | 401.51 ± 7.19§ | 399.76 ± 14.64§ |
n = number of animals per group (5 measurements per animal, except for single body weight and tBMI measurements)
BW body weight, DBP diastolic blood pressure, HR heart rate, SBP systolic blood pressure, tBMI body mass indexed for tibia length
*p < 0.05 vs. CON; +p < 0.05 vs. D-CON; §p < 0.05 vs. BB; ^p < 0.05 vs. ACEI; ˇp < 0.05 vs. AA; #p < 0.05 vs. day 0; †p < 0.05 vs. day 7 (for SBP, DBP and HR) or day 49 (for BW or tBMI)