Qualitative assessment of the in vivo tumor contrast as a function of time. Mice with HCT116-SSTR2 tumors were intravenously injected with 2 nmol of -MMC(IR800)-TOC and imaged with the OnLume imager at 3, 24, 48, and 72 h post-injection (, cohort shown in Fig. 2 in the Supplementary Material). For these representative mice, NIRF images are all on the same relative scale and overlaid on the WL reflectance captured simultaneously under ambient light. The tumor is labeled by the blue star (*), and the kidney is labeled with two red stars (**). FAUs, fluorescence arbitrary units.