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. Author manuscript; available in PMC: 2021 Jan 13.
Published in final edited form as: ACS Biomater Sci Eng. 2019 Dec 10;6(1):308–319. doi: 10.1021/acsbiomaterials.9b01520

Fig 5. DOE Approach Predicted Hydrogel Design Properties to Control the Mesh Structure of Binary Alginate Hydrogels.

Fig 5.

DOE was used to identify properties that could alter the cross-link density and mesh size of alginate hydrogels with MVM (low G-block content) and MVG (high G-block content) polymers. Response surface maps of hydrogel properties effect on cross-linking density are provided (A). Altering polymer volume fraction, the ratio of MVG to MVM polymers and G-block content of hydrogels predicted a large range of adjustable hydrogel mesh sizes (B). In figure panel A, the heat color map represents the range of cross-link density. In figure panel B, the heat color map represents the mesh size range (A–B, n = 10).